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IGF-1 LR3 is a synthetic analog of insulin-like growth factor-1 with amino acid substitutions at positions 3 and extended half-life (2030 hours vs 10 minutes for endogenous IGF-1), enabling systemic anabolic signaling without growth hormone involvement

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What the STEP trials established about semaglutide The clinical backbone for semaglutide in weight management is the STEP program, published in The New England Journal of Medicine in 2021

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